Effects of omega-3 fatty acids on chronic pain: a systematic review and meta-analysis.

ABSTRACT:

Background

Chronic pain afflicts approximately 20% of the global adult population and is frequently undertreated, with available pharmacologic options often associated with significant long-term adverse effects. Although omega-3 fatty acids are known for their anti-inflammatory and immunomodulatory effects, current clinical evidence regarding their efficacy in pain management remains inconclusive.

Objective

To determine how well omega-3 fatty acids reduce chronic pain, and to investigate how factors like disease type, dosage, treatment duration, and study design influence their effectiveness.

Methods

We searched four databases (PubMed, Embase, Cochrane Library, and Web of Science) from inception to 14 February 2025 with no language restrictions. Forty-one randomised c

SUBMITTER: Xie L 

PROVIDER: S-EPMC12627051 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature