Influence of diabetes on the efficacy of DL-3-n-butylphthalide in post-stroke cognitive impairment: a 12-month prospective cohort study.

ABSTRACT:

Objective

Diabetic chronic hyperglycaemia amplifies oxidative stress, microvascular injury, and insulin-resistant neuroinflammation, counteracting the pro-angiogenic, mitochondrial-protective, and anti-apoptotic effects of DL-3-n-butylphthalide (NBP). It remains unknown whether glycaemic status modulates the long-term cognitive benefits of NBP after ischaemic stroke (IS). This study compared 12-month efficacy of NBP on cognition between non-diabetic and diabetic patients with subacute IS.

Methods

We conducted a community-based prospective cohort study involving 594 patients who had an ischemic stroke 1-6 months prior and no baseline cognitive impairment. Participants were assigned to either the NBP treatment group or the usual care group. MMSE scores were assessed at baselin

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12627063 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature