Variations in body condition score, inflammatory and metabolic biomarkers predict cognitive changes in clinically healthy senior cats.

ABSTRACT:

Objectives

The present study aimed to identify immune, metabolic, and hematological biomarkers, among those commonly monitored in clinical practice, that are predictive of age-related behavioral and cognitive changes in clinically healthy elderly cats, with the objective of highlighting potential patterns of inflammaging.

Methods

A cross-sectional observational study was conducted at two veterinary institutions and involved 90 clinically healthy, privately owned domestic cats aged 7-16 years. All cats underwent physical examinations, laboratory, and behavioral screenings. Serum concentrations of the pro-inflammatory cytokine interleukin-1beta (IL-1β) and the anti-inflammatory cytokine IL-10 were measured using ELISA as markers of peripheral inflammation. Behavioral and cogni

SUBMITTER: Memoli H 

PROVIDER: S-EPMC12627069 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature