Duplication and positive selection among hominin-specific PRAME genes.

ABSTRACT:

Background

The physiological and phenotypic differences between human and chimpanzee are largely specified by our genomic differences. We have been particularly interested in recent duplications in the human genome as examples of relatively large-scale changes to our genome. We performed an in-depth evolutionary analysis of a region of chromosome 1, which is copy number polymorphic among humans, and that contains at least 32 PRAME (Preferentially expressed antigen of melanoma) genes and pseudogenes. PRAME-like genes are expressed in the testis and in a large number of tumours, and are thought to possess roles in spermatogenesis and oogenesis.

Results

Using nucleotide substitution rate estimates for exons and introns, we show that two large segmental duplications, of six and

SUBMITTER: Birtle Z 

PROVIDER: S-EPMC1262708 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature