Genetic signatures underlining circulating lipids display causal effects on schizophrenia.

ABSTRACT: Schizophrenia (SZ) is a serious mental illness with unclear pathophysiologic mechanisms. Although some studies have found evidence of altered circulating lipid metabolites in patients with SZ, the causative relationship between the two remains unclear. Based on publicly summarized-level GWAS data, we investigated the bidirectional causative relationship between SZ (53,386 cases and 77,258 controls) and 233 traits describing circulating metabolites (136,016 participants) using a two-sample Mendelian randomization (MR) technique. For each outcome, we estimated causal effects of each exposure using the inverse variance weighted (IVW), MR-Egger, and weighted median methods, while sensitivity was gauged using the MR-Egger intercept and Cochran's Q test. Two circulating lipid metabolites (the ra

SUBMITTER: Du J 

PROVIDER: S-EPMC12627080 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature