A TNF-induced gene expression program under oscillatory NF-kappaB control.

ABSTRACT:

Background

The cytokine tumor necrosis factor (TNF) initiates tissue inflammation, a process mediated by the NF-kappaB transcription factor. In response to TNF, latent cytoplasmic NF-kappaB is activated, enters the nucleus, and induces expression of inflammatory and anti-apoptotic gene expression programs. Recently it has been shown that NF-kappaB displays two distinct activation modes, monophasic and oscillatory, depending on stimulus duration. Characterization of temporal expression patterns for the NF-kappaB network and determination of those genes under monophasic- or oscillatory control has not been experimentally addressed.

Results

To identify the kinetics of NF-kappaB-dependent gene expression and determine whether these two types of NF-kappaB translocation modes cont

SUBMITTER: Tian B 

PROVIDER: S-EPMC1262712 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature