Seven Hypoxia and Immune-Related Features Predict Prognosis in Patients with Hepatocellular Carcinoma.

ABSTRACT:

Background

The role of hypoxia and immunity in the progression of hepatocellular carcinoma (HCC) was highly critical. However, there were few application-based studies on hypoxia and immune molecules in HCC prognosis prediction. This study aims to reveal the prognostic significance of hypoxia- and immune-related genes in HCC.

Methods

We identified the hypoxia- and immune-related differentially expressed genes (HIDEGs) from the Cancer Genome Atlas (TCGA). Seven HIDEGs associated with the prognosis of HCC were identified with the Cox regression and LASSO analysis. The prognosis model was validated in both the TCGA (n = 420) and Gene Expression Omnibus (GEO) (GSE14520-GPL3921, n = 222) databases. CIBERSORT was applied to measure the fractions of immune cell types. The drug sens

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12627134 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature