Comparative analysis of RNA regulatory elements of amino acid metabolism genes in Actinobacteria.

ABSTRACT:

Background

Formation of alternative structures in mRNA in response to external stimuli, either direct or mediated by proteins or other RNAs, is a major mechanism of regulation of gene expression in bacteria. This mechanism has been studied in detail using experimental and computational approaches in proteobacteria and Firmicutes, but not in other groups of bacteria.

Results

Comparative analysis of amino acid biosynthesis operons in Actinobacteria resulted in identification of conserved regions upstream of several operons. Classical attenuators were predicted upstream of trp operons in Corynebacterium spp. and Streptomyces spp., and trpS and leuS genes in some Streptomyces spp. Candidate leader peptides with terminators were observed upstream of ilvB genes in Corynebacterium

SUBMITTER: Seliverstov AV 

PROVIDER: S-EPMC1262725 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature