Induction chemotherapy followed by definitive chemoradiation in patients with inoperable esophageal squamous cell carcinoma: a multicenter retrospective study.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) remains a global health challenge, characterized by significant geographic variations in incidence, risk factors, and treatment paradigms. While definitive chemoradiotherapy (CRT) is the cornerstone of therapy for inoperable locally advanced disease, the role of induction chemotherapy followed by CRT (CT-CRT) remains underexplored, particularly in Western populations. This study aimed to assess the survival outcomes of CRT and CT-CRT in a multicenter cohort with inoperable locally advanced ESCC.

Methods

This retrospective multicenter cohort study included 92 patients with inoperable stage II-IVA ESCC treated with CRT or CT-CRT between May 2015 and January 2024. Disease-free survival (DFS), overall survival (OS), distant me

SUBMITTER: Sahin TK 

PROVIDER: S-EPMC12627277 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature