Hemispheric disconnection as a basis for neurodegeneration in apraxia and Alzheimer's disease.

ABSTRACT:

Introduction

Apraxias, traditionally viewed as executive disorders secondary to focal lesions, are here reformulated as systemic outcomes of progressive interhemispheric disconnection-particularly relevant in the early stages of Alzheimer's disease.

Objective

To propose an integrated theoretical model that redefines apraxias from a neurosemiotic and embodied perspective, linking them to corpus callosum degeneration and the breakdown of sensorimotor gesture networks.

Methods

This contribution is based on a transdisciplinary conceptual review, integrating data from neuroscience, body semiotics, phenomenology, and recent clinical studies. The reflection is supported by a synthesis of neuroanatomical, cognitive, and behavioral findings regarding proprioceptive function an

SUBMITTER: Sanna M 

PROVIDER: S-EPMC12627278 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature