Adenylosuccinate lyase (ADSL) is a pan-cancer prognostic and immune biomarker with distinct roles in hepatocellular carcinoma.

ABSTRACT:

Background

The role of ADSL in various types of cancer remains inadequately understood. We encompassed a comprehensive examination of the mechanistic features of ADSL and explored its viability as a broad-spectrum predictor for malignancies.

Methods

Through a comprehensive pan-cancer examination, methylation assessment, immune infiltration evaluation, and further integration of single-cell transcriptome analysis, cellular communication, nomogram modeling, and prospective drug prediction in hepatocellular carcinoma (HCC), we have undertaken a thorough investigation of the biological roles of ADSL in neoplasms, especially in HCC.

Results

ADSL is markedly overexpressed in neoplastic tissues. ADSL downregulation is significantly correlated with improved overall survival (

SUBMITTER: Zhu W 

PROVIDER: S-EPMC12627297 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature