Effect of low bicarbonate substitution solution on CO₂ removal rate in the combined system of extracorporeal CO₂ removal and continuous renal replacement therapy.

ABSTRACT:

Background

The concurrent application of extracorporeal carbon dioxide removal (ECCO₂R) and continuous renal replacement therapy (CRRT) delivers essential respiratory and renal support. However, the use of bicarbonate (HCO₃⁻) in substitution solution increases the external HCO₃⁻ load and affect the carbon dioxide removal rate (VCO₂). This study aims to investigate the influence of low bicarbonate substitution solution on VCO₂ within the combined ECCO₂R-CRRT system.

Methods

This crossover study was conducted with hypercapnic pigs and patients with acute respiratory distress syndrome (ARDS). In pigs, we tested two extracorporeal blood flow rates (200 and 350 mL/min) alongside three continuous veno-venous hemofiltration (CVVH) strategies: a control group receiving ECCO₂R alone

SUBMITTER: Qian Z 

PROVIDER: S-EPMC12627315 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature