High expression of GRB14 is associated with cancer progression and poor prognosis in gastric cancer.

ABSTRACT:

Background

Growth factor receptor-bound protein 14 (GRB14) has emerged as a significant regulator in cancer progression and prognosis across certain cancer types. Nevertheless, its role in gastric cancer (GC) remain poorly characterized.

Methods

We conducted a comprehensive investigation of GRB14 in GC, integrating bioinformatics analysis with experimental validation. The prognostic significance and functional profile of GRB14 was evaluated through survival analysis and GSEA. Additionally, we analyzed the variations in immune cell infiltration and responses to immunotherapy between groups with low and high expression levels of GRB14. To confirm GRB14 expression in GC tissues, we utilized RT-qPCR, western blot and immunohistochemistry (IHC) analysis. Subsequently, functional

SUBMITTER: Hu H 

PROVIDER: S-EPMC12627322 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature