CDK8 mediated inflammatory microenvironment aggravates osteoarthritis progression.

ABSTRACT:

Introduction

Cyclin-Dependent Kinase 8 (CDK8), a CDK family member, regulates the development of inflammatory processes through transcriptional activation. The involvement of CDK8 in osteoarthritis (OA) progression is not yet understood.

Objectives

This study aims to investigate whether CDK8, through its transcriptional regulatory functions, collaborates with NF-κB in chondrocytes to regulate the transcription of senescence-associated secretory phenotype (SASP) genes, thereby exacerbating the inflammatory microenvironment in the progression of osteoarthritis (OA), and to explore the specific mechanisms involved.

Methods

The effects of CDK8 silencing or overexpression will be assessed by measuring OA pathological markers through H&E staining, immunoblotting, Western bl

SUBMITTER: Lin Z 

PROVIDER: S-EPMC12627336 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature