Molecular and cellular morphology of placenta unveils new mechanisms of reproductive immunology.

ABSTRACT:

Introduction

Despite of numerous studies of the placenta, some molecular and cellular characteristics, particularly the relationship among different cell types, have not been well understood. We aim to investigate the basic and intricate details of cellular and molecular elements in early and late phase placentas to gain better understanding of the immune regulation of human reproductive process.

Methods

A novel combination of techniques of spatial transcriptomics(ST), multiple immunohistochemistry, and a dual labeling combining immunohistochemistry and (fluorescence in situ hybridization) FISH on normal and ectopic pregnancy and animal models was employed to investigate the placenta at tissue, cell, protein and molecular levels and to trace the fetal and maternal origin of

SUBMITTER: Li P 

PROVIDER: S-EPMC12627341 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature