Development of novel broad-spectrum amphipathic antimicrobial peptides against multidrug-resistant bacteria through a rational combination strategy.

ABSTRACT:

Introduction

In recent years, cationic amphipathic antimicrobial peptides (AMPs) have shown great promise in combating antibiotic resistance on account of their distinctive membrane-disruptive mechanism. However, the clinical application of AMPs is restricted by their unsatisfactory stability and safety. Although attempts have been made to improve the stability and safety of AMPs, many of them are accompanied by a decline in their antimicrobial activity and bacterial selectivity.

Objectives

To develop AMPs with excellent and balanced antimicrobial activity, stability, and safety using a combination strategy.

Methods

A series of sC18_4b-derived peptide analogues were designed by a combination strategy of subtly adjusting the charges, hydrophobic properties, a

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12627342 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature