Astragaloside IV ameliorates autism-like behaviors in BTBR mice by modulating Camk2n2-dependent OXPHOS and neurotransmission in the mPFC.

ABSTRACT:

Introduction

Autism spectrum disorder (ASD) represents a multifaceted set of neurodevelopmental conditions marked by social deficits and repetitive behaviors. Astragaloside IV (ASIV), a natural compound derived from the traditional Chinese herb Astragali Radix, exhibits robust neuroprotective effects. However, whether ASIV can ameliorate behavioral deficits in ASD remains unknown.

Objectives

This work aimed to determine the efficacy and molecular mechanisms of ASIV in ASD.

Methods

The autistic BTBR T + tf/J (BTBR) mice were used in this study. Behavioral tests were performed to assess the ASD-like phenotypes. The neurotransmitter levels and synaptic transmission were evaluated by high-performance liquid chromatography and whole-cell patch clamp recordings, respectivel

SUBMITTER: Chen M 

PROVIDER: S-EPMC12627349 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature