Impact of prior chemotherapy on nanoliposomal irinotecan with fluorouracil and folinic acid for unresectable pancreatic cancer: a retrospective analysis of data from the multicenter NAPOLEON-2 study.

ABSTRACT:

Background

Nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard regimen for patients with unresectable or recurrent pancreatic cancer (urPC) after gemcitabine-based chemotherapy. However, little is known about the clinical impact of previous chemotherapy on the effects of NFF in the real world.

Objectives

We retrospectively evaluated whether the efficacy and safety of NFF differed depending on the history of prior chemotherapy among urPC patients receiving NFF.

Design

This study was conducted using the real-world data of Japanese patients with urPC who received NFF in the multicenter NAPOLEON-2 study.

Methods

We compared the efficacy and adverse events (AEs) after NFF initiation between previous irinotecan users and non-users, fluorou

SUBMITTER: Koike T 

PROVIDER: S-EPMC12627385 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature