Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection.

ABSTRACT:

Objective

The aim of this study was to investigate the potential molecular mechanisms by which taurine protects against cartilage degeneration.

Methods

The anterior cruciate ligament transection (ACLT) surgery was used to construct an animal model of osteoarthritis (OA). Metabolomics was used to identify characteristic metabolites in osteoarthritic chondrocytes. Transcriptomics and metabolomics were used to explore potential mechanisms by which the small molecule metabolite taurine protects against inflammatory chondrocyte damage. Cell transfection and small molecule inhibitors/agonists were used to validate the molecular mechanisms by which taurine protects inflammatory chondrocytes in vitro. Finally, adeno-associated virus and small molecule inhibitors/agonists were used t

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12627399 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature