Validation of a screening score model to predict the development of retinopathy of prematurity.

ABSTRACT: Retinopathy of prematurity (ROP) is a leading cause of preventable blindness in preterm infants, with a disproportionate burden in low- and middle-income countries. Screening criteria from high-income settings may not be directly applicable in these contexts. We developed and validated two pragmatic risk-based screening models using multicenter Indonesian neonatal data: Model A (FiO₂-based) and Model B (SpO₂-based). Significant predictors included intrauterine growth restriction, oxygen exposure, exchange transfusion, and socioeconomic status. Internal validation showed moderate discrimination (AUC 0.719-0.732) with sensitivities of 77-86% and specificities of 44-58%. The bedside operational score form is presented for clinical use. External validation in 163 infants (gestational age 25-37

SUBMITTER: Siswanto JE 

PROVIDER: S-EPMC12627429 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature