Single-cell integration analysis reveals molecular signatures of the tumor microenvironment in early-onset colorectal cancer.

ABSTRACT: The incidence of early-onset colorectal cancer (CRC), defined as cases diagnosed in individuals under 50, is rising globally. However, its molecular and immune characteristics remain poorly understood. In this study, we analyze single-cell RNA sequencing data from 168 CRC patients, aged 22 to 91, to investigate differences between early-onset and standard-onset CRC. We find a reduced proportion of tumor-infiltrating myeloid cells, a higher burden of copy number variations, and decreased tumor-immune interactions in early-onset CRC. Additionally, immune signatures unique to early-onset CRC are associated with differential responses to immunotherapy, underscoring the need for tailored therapeutic strategies for this group of patients. These findings provide valuable insights into the molecul

SUBMITTER: Peng T 

PROVIDER: S-EPMC12627461 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature