Critically ill patients with a reverse blood pressure dipping phenotype at increased risk for delirium and death.

ABSTRACT: The ICU environment is disruptive to a patient's biological rhythms where sleep-wake cycles are often desynchronized from the environmental day-night changes. This puts patients at increased risk to develop delirium with consequent fiscal pressure for the health care system. An underappreciated dimension is how time-specific patient phenotypes in the critical care environment relate to clinical outcomes. We set out to analyze how rhythmic components (or the lack thereof) in physiological data streams sampled at high resolution in the ICU were associated with the future incidence of delirium and death. To offer cues for further interrogation into mechanism and risk prognosis, we examined differences in 24-hour fluctuations of clinical labs in ICU patient populations at risk. Rhythmic compon

SUBMITTER: El Jamal N 

PROVIDER: S-EPMC12627465 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature