Loss of p190A RhoGAP induces aneuploidy and enhances bladder cancer cell migration and invasion by modulating actin dynamics.

ABSTRACT: p190A has been studied across various cancer types, and mutation rates of up to 20% were observed in some cancers, supporting the significance of p190A in carcinogenesis. Since the relevance of p190A in bladder cancer has not been addressed so far, we attempted to explore it. Evaluation of TCGA high-throughput sequencing datasets revealed p190A mutations in up to 8% of bladder cancer samples across several studies. Employing immunohistochemistry on tissue microarray that included 202 BC patient samples, we observed that lower p190A expression correlates with increased invasiveness and poorer survival outcomes. These findings suggested that p190A may have a tumor suppressor function in bladder tissue, consistent with its anticipated function in ploidy-control. p190A knockdown resulted in ch

SUBMITTER: Kang Q 

PROVIDER: S-EPMC12627482 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature