Increased circulating heat shock protein Hsp70 serum levels as a potential biomarker in bronchial asthma patients.

ABSTRACT: The 70 kDa major stress-inducible member of the heat shock protein 70 family Hsp70 plays an important pathogenic role in inflammatory and autoimmune diseases, including bronchial asthma, and therefore the detection of the levels of the circulating chaperone in serum or plasma could be employed as a diagnostic and prognostic marker. The prospective open single-center study enrolled 78 adult bronchial asthma patients and age-matched healthy volunteers (n = 78). Serum HSP70 levels were measured using the ELISA Kit. Serum concentrations of HSP70 as detected by the R&D Systems Hsp70 ELISA in asthmatics patients were significantly higher as compared to control subjects constituting 31.2 ng/ml (p < 0.001) and were negatively correlated with FEV1 (forced expiratory volume in 1 s) and FEV1/FVC in a

SUBMITTER: Churyukina E 

PROVIDER: S-EPMC12627502 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature