HMMR has oncoprotein-like properties in neuroblastoma cells and high HMMR expression has independent prognostic potential in neuroblastomas.

ABSTRACT: Neuroblastoma (NB) is a devastating childhood cancer where most tumours have no clear oncogenic driver. We aimed to define whether HMMR, an oncogene-like protein in several cancers, harbors similar potential in neuroblastoma cells. HMMR is a hyaluronic acid (HA) receptor and a mitotic microtubule regulator. We show that high HMMR expression does not correlate well with MYCN driver expression and moreover statistically HMMR is an independent prognostic indicator of poor survival in NB patients. In cultured KELLY neuroblastoma cells, removal of the HMMR protein suppresses proliferation, motility and clonogenic capacity, while xenografts of HMMR-deficient cells imparted longer animal survival compared to wild type cells. Loss of motility in culture was compensated by addition of exogenous HA,

SUBMITTER: Karapouliou C 

PROVIDER: S-EPMC12627537 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature