Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events.

ABSTRACT:

Background

High-dose steroids constitute the cornerstone of first-line treatment for immune-related adverse events (irAEs) associated with immune checkpoint inhibitors, but compromise antitumor immunity. A deeper understanding of irAEs and their response to steroids can improve management.

Methods

Using a multi-omics approach, we investigated blood- and tissue-based correlates of steroid response, focusing on gastro-intestinal irAEs, in the largest cohort to date.

Results

Here we show clear trends for elevated T_C1/T_C17 CD8⁺ T cells and Th1/Th7-associated interleukins before steroid initiation, and persistent (CD8⁺) T cell activation after initiation of steroids in blood of steroid non-responders. Cross-sectional analysis of

SUBMITTER: van Eijs MJM 

PROVIDER: S-EPMC12627558 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature