Exploring the mechanism of Notopterygii rhizoma et radix in the treatment of psoriasis using a network Pharmacology approach and experimental validation.

ABSTRACT: Psoriasis is a prevalent chronic inflammatory skin disease that significantly reduces patients' quality of life. Current treatments have limited efficacy and severe side effects, necessitating the development of new drugs. Notopterygii rhizoma et radix (Qiang Huo, QH), a Traditional Chinese Medicine (TCM) herb commonly studied for psoriasis patterns and treatment, requires further clarifications of its pharmacological mechanism. This study first verified the therapeutic effects of QH on Imiquimod (IMQ)-induced psoriasis-like mice and LPS-induced keratinocyte (HaCaT) model. Our study showed QH significantly alleviated skin symptoms, improved pathological changes, inhibited HaCaT proliferation, and reduced inflammation. Network pharmacology was then applied to explore QH's potential mechanis

SUBMITTER: Liu J 

PROVIDER: S-EPMC12627576 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature