A standardized and reproducible rodent model of esophagogastric anastomosis healing following esophageal transection.

ABSTRACT: Experimental animal models are indispensable for investigating disease mechanisms and therapeutic strategies. Esophageal resection remains the only curative treatment for esophageal cancer, but disruption of the esophagogastric anastomosis is associated with high morbidity and mortality. To better understand anastomotic healing and related complications, a simple and reproducible rodent model is required. In this study, we developed a novel, reliable technique for establishing esophagogastric anastomosis in rats. Hand-sewn end-to-end anastomoses were performed following esophageal dissection, with a 4-mm silicone catheter placed from the gastrotomy into the distal esophagus to facilitate suturing. Anastomoses were constructed with continuous nonabsorbable sutures in 10 male Sprague-Dawley

SUBMITTER: Kovac I 

PROVIDER: S-EPMC12627617 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature