Chemical profiling by LC-MS/MS and GC-MS and biological activity assessment of different extracts of Portulaca oleracea through in-vitro and in-silico approaches.

ABSTRACT: In this study, the phenolic compound profile and essential oil composition of Portulaca oleracea L. collected from the Bulancak (Giresun) region of Türkiye were investigated in detail by LC-MS/MS and GC-MS techniques. The obtained data were then correlated with multifaceted biological activity tests and in-silico molecular modelling. In the scope of the study, the anti-diabetic (inhibition of α-amylase and α-glucosidase), anti-inflammatory (inhibition of protein denaturation) and anti-hemolytic effects were evaluated in conjunction with the chemical composition data. The results of the LC-MS/MS analysis indicate that p-coumaric acid is the predominant phenolic, with a concentration of 1228.10 mg/kg. The presence of other phenolics was also detected, including vanillin (5.12 mg/kg), caffeic

SUBMITTER: Gungor OY 

PROVIDER: S-EPMC12627655 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature