Hypothalamic functional connectivity, depressive symptoms, and post-treatment SOREMPs in narcolepsy type 1: links to sleep latency and mediation mechanisms.

ABSTRACT: Narcolepsy type 1 (NT1) is characterized by sleep-onset rapid eye movement periods (SOREMPs), reflecting dysregulated rapid eye movement (REM) sleep control. Treatment response variability in SOREMP persistence remains poorly understood, particularly regarding hypothalamic functional connectivity (FC) and depressive symptoms. This study investigated clinical, polysomnographic, and neuroimaging differences between NT1 patients with low (0-1) versus high (≥2) post-treatment SOREMPs, and explored whether hypothalamic FC mediates the relationship between depressive symptoms and SOREMPs outcomes. One hundred ten NT1 patients were categorized into low (n = 62) and high (n = 48) post-treatment SOREMPs groups. Demographic, clinical variables (symptoms and questionnaires), and polysomnography (PSG)

SUBMITTER: Wang M 

PROVIDER: S-EPMC12627739 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature