Rapid NGS Analysis on Google Cloud Platform: Performance Benchmark and User Tutorial.

ABSTRACT: Next-Generation Sequencing (NGS) is being increasingly adopted in clinical settings as a tool to increase diagnostic yield in genetically determined pathologies. However, for patients in critical conditions the time to results of data analysis is crucial for a rapid diagnosis and response. Sentieon DNASeq and Clara Parabricks Germline are two widely used pipelines for ultra-rapid NGS analysis, but their high computational demands often exceed the resources available in many healthcare facilities. Cloud platforms, like Google Cloud Platform (GCP), offer scalable solutions to address these limitations. Yet, setting up these pipelines in a cloud environment can be complex. This work provides a benchmark of the two solutions, and offers a comprehensive tutorial aimed at easing their implementa

SUBMITTER: Franzoso E 

PROVIDER: S-EPMC12627752 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature