Longitudinal Brain Atrophy Patterns in Early MOG-Antibody Associated Disease and Relapsing Multiple Sclerosis.

ABSTRACT:

Background

Myelin oligodendrocyte glycoprotein antibody-associated disease can manifest as a relapsing or monophasic condition. Although several MRI studies have shown evident gray and white matter atrophy compared to healthy controls, little is known about regional brain volume dynamics in myelin oligodendrocyte glycoprotein antibody-associated disease over time.

Methods

In this study, we performed an explorative voxel-based morphometry to detect brain volumetric differences between myelin oligodendrocyte glycoprotein antibody-associated disease (N = 27), relapsing multiple sclerosis (N = 40)-both in early disease stages-and healthy controls (N = 45). Furthermore, we investigated the longitudinal brain volume changes over a 2-year follow-up period in myelin oligodendrocyte

SUBMITTER: Ladopoulos T 

PROVIDER: S-EPMC12627754 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature