Structural connectivity abnormalities in suicidal thoughts and behaviours: a meta-analysis.

ABSTRACT: Suicidal thoughts and behaviours (STBs) are major public health concerns. Despite much research focus on grey matter abnormalities in STBs, the study of white matter tracts that connect the brain regions implicated in STBs has received relatively less attention. Hence, we conducted the first meta-analysis of whole-brain voxel-based diffusion tensor imaging studies in STBs to elucidate the most robust white matter microstructure abnormalities relative to controls. Fourteen DTI datasets were included, comprising 289 individuals with a history of STBs and 506 controls. Anisotropic effect-size signed differential mapping, a voxel-based meta-analytic method, was used to examine regions of altered fractional anisotropy (FA) in individuals with STBs compared to controls. Individuals with a histor

SUBMITTER: Lim L 

PROVIDER: S-EPMC12627832 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature