Zn-doped CaP coating equips Ti implants with corrosion resistance, biomineralization, antibacterial and immunotolerant activities.

ABSTRACT:

Introduction

Chronic inflammation leading to implant failure present major challenges in orthopedics, dentistry, and reconstructive surgery. Titanium alloys, while widely used, often provoke inflammatory complications. Zinc (Zn)-doped calcium phosphate (CaP) coatings offer potential to enhance implant integration by improving corrosion resistance, bioactivity, and immunocompatibility.

Objectives

The objective of the study was to develope novel coating composition based on zinc-doped CaP coatings on Ti64 alloy implants that for the first time combines improved corrosion resistance, antibacterial properties and principally improved compatibility with the innate immunity primarily due to the proper programming of resident tissue macrophages to promote long-term implant acceptan

SUBMITTER: Parau AC 

PROVIDER: S-EPMC12627863 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature