CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway.

ABSTRACT:

Introduction

Pancreatic cancer (PC) cannot currently be completely cured and has a poor prognosis. Necroptosis is a distinct form of regulated cell death that differs from both necrosis and apoptosis. Understanding the role of necroptosis during PC progression would open new avenues for targeted therapy.

Objectives

The purpose of this study is to examine the impact of necroptosis on the progression of PC and related mechanisms.

Methods

RNA sequencing was performed to identify necroptosis-related genes that are differentially expressed in PC tissues. The biological functions of CHMP4C and its necroptosis effects were determined in vitro and in vivo. RNA immunoprecipitation, MeRIP-qPCR, Co-immunoprecipitation assays were conducted to evaluate the interaction among CHMP4

SUBMITTER: Yu L 

PROVIDER: S-EPMC12627866 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature