Blood pressure and Alzheimer's disease biomarkers in cognitively unimpaired adults: a multicenter study.

ABSTRACT:

Background

Hypertension is a modifiable risk factor for dementia, potentially influencing Alzheimer's disease (AD) pathology. Understanding this relationship is essential for developing interventions to reduce dementia risk.

Objectives

We investigated cross-sectional and longitudinal associations between blood pressure and AD biomarkers in cerebrospinal fluid (CSF) and amyloid (Aβ) positron emission tomography (PET) in cognitively unimpaired adults.

Design

Prospective observational study.

Setting

We analyzed data from cognitively unimpaired participants from three observational prospective European studies: ALFA+ (NCT02485730), EPAD-LCS (NCT02804789), and AMYPAD PNHS (EudraCT: 2018-002,277-22).

Measurements

ALFA+ participants had either CSF biomarkers (C

SUBMITTER: Osset-Malla M 

PROVIDER: S-EPMC12627890 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature