Brain patterns and risk factors in the FINGER RCT multimodal lifestyle intervention.

ABSTRACT:

Importance

Despite the emergence of anti-amyloid therapies for Alzheimer's disease, targeting modifiable risk factors remains the most effective primary prevention strategy for dementia. While cognitive benefits of multimodal lifestyle interventions have been demonstrated, the underlying effects on brain structure remain unclear, likely due to heterogeneity in brain structure among at-risk individuals.

Objective

To investigate how distinct subgroups of at-risk individuals, defined by cortical and subcortical grey matter (GM) patterns, differ in their response to the FINGER intervention, as well as in their demographic, vascular, and lifestyle profiles.

Design

Observational study employing unsupervised clustering of MRI-based cortical thickness and subcortical volume m

SUBMITTER: Lorenzon G 

PROVIDER: S-EPMC12627893 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature