The role for artificial intelligence in identifying combination therapies for Alzheimer's disease.

ABSTRACT: Despite substantial investment in biomedical and pharmaceutical research over the past two decades, the global prevalence of Alzheimer's disease (AD) and AD-related dementias (AD/ADRD) is still rising. This underscores the significant unmet need for identifying effective disease-modifying therapies. Here, we provide a critical perspective on the application of data science and artificial intelligence (AI) to the rational design of drug combinations in AD and ADRD, addressing their potential to transform therapeutic development. We examine AI's current and prospective capabilities in therapeutic discovery, identify areas where AI-driven strategies can enhance drug combination development, and outline how multidisciplinary professionals in the field, including clinical trialists, neuropsychi

SUBMITTER: Cheng F 

PROVIDER: S-EPMC12627895 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature