Genetic variants associated with gout identified through a genome-wide study in the UK biobank (N = 150 542).

ABSTRACT: Gout is a prevalent and painful form of inflammatory arthritis associated with hyperuricemia, which leads to monosodium urate crystal deposition in joints and surrounding tissues, triggering acute inflammatory responses. This disease is also closely linked to serious comorbidities, including cardiovascular diseases, chronic kidney diseases, diabetes, and increased mortality risk, significantly impacting global health. In this study, we conducted a comprehensive genome-wide association study (GWAS) based on the UK Biobank pain questionnaire 2019, comprising 10 474 gout cases and 140 068 controls, identifying 13 loci associated with gout. These findings were further explored in the FinnGen cohort, with 10 loci being replicated significantly. Sex-stratified analyses revealed notable differenc

SUBMITTER: Tao Y 

PROVIDER: S-EPMC12627942 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature