Development of a chromene-based fluorescent and colorimetric sensor for the sensitive detection of calcium ions in a complex medium: a detailed DFT and experimental approach.
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ABSTRACT: Calcium plays a key role in various biochemical processes and cellular functions in the human body; its imbalance can cause severe hyper- and hypo-calcemic medical conditions. In this research work, we developed a novel AIE-active chromene-based fluorescent sensor, CFN (DMF, λ exc = 330 nm, λ em = 476 nm), through an easy Knoevenagel condensation reaction with solvatochromic characteristics. The synthesized CFN sensor exhibited excellent fluorescence enhancement with a blue shift in 90% aqueous media (9 : 1, H2O/DMF, λ exc = 330 nm, λ em = 410 nm). Blue shift in the fluorescence spectrum indicates the formation of H-aggregates, which is further supported by dynamic light scattering (DLS) results. The CFN sen
SUBMITTER: Khurshid K
PROVIDER: S-EPMC12627990 | biostudies-literature | 2025 Nov
REPOSITORIES: biostudies-literature
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