Endothelial MerTK impairment accelerates the development of atherosclerosis.

ABSTRACT:

Rationale

Atherosclerosis is a chronic inflammatory disease primarily affecting large arteries and is the leading cause of cardiovascular disease. MER proto-oncogene tyrosine kinase (MerTK) plays a key role in regulating efferocytosis, a process for the clearance of apoptotic cells. This study investigates the specific contribution of endothelial MerTK to atherosclerosis development.

Methods

Big data analytics, human microarray analyses, proteomics, and a unique mouse model with MerTK deficiency in endothelial cells (MerTK^flox/floxTie2^Cre) were utilized to elucidate the role of endothelial MerTK in atherosclerosis development.

Results

Our big data analytics, encompassing approximately 98,881 cross analyses including 234 analyses for atheroscleros

SUBMITTER: Liu S 

PROVIDER: S-EPMC12628026 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature