Updated Reference Limits for Liver Blood Tests With Validation Against Long-Term Liver-Related Outcomes.

ABSTRACT:

Background and aims

Liver blood tests are widely used, but their reference limits may not reliably predict long-term liver-related risks. Previous studies to establish reference limits often lacked rigorous exclusion of individuals with undiagnosed liver disease or associated risk factors. This study aims to establish more precise reference limits in a rigorously defined healthy middle-aged population and validate their clinical relevance against major adverse liver outcomes (MALOs).

Methods

We analysed 5412 participants from the Finnish population-based Health 2000 Survey, systematically excluding individuals with baseline or future liver disease during the next 10 years, advanced fibrosis, liver-related risk factors, hepatotoxic medication use, or systemic conditions to de

SUBMITTER: Aberg F 

PROVIDER: S-EPMC12628042 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature