Circulating Tumor Cells and Clinical Outcomes in Men with Metastatic Castration-sensitive Prostate Cancer Treated with Enzalutamide and Docetaxel: An Analysis of the ENZADA Trial.

ABSTRACT: We evaluated the prognostic value of circulating tumor cell (CTC) counts and androgen receptor splice variant 7 (AR-V7) status at baseline and after docetaxel in the previously published ENZADA trial. We analyzed data for 35 participants with both baseline and postdocetaxel CTC counts. CTC count status at two thresholds (≥2 vs <2 cells/μl; ≥3 vs <3 cells/μl) was not prognostic for a 26-wk or 52-wk prostate-specific antigen (PSA) complete response (CR), overall survival (OS), or time to castration resistance (TTCR). CTC count status (>0 vs 0 cells/μl) after docetaxel was not associated with 26-wk PSA CR, OS, or TTCR. However, there was a trend towards a higher 52-wk PSA CR rate among those with detectable CTCs after docetaxel (92% vs 52%; p = 0.03). A binary variable indicating the c

SUBMITTER: Brown LC 

PROVIDER: S-EPMC12628052 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature