Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration.

ABSTRACT: Initial implant-related infection and subsequent poor osseointegration are the main causes of implant placement failure. The extracellular microenvironment is an important mediator of behaviors of cell and bacteria; however, spontaneously dynamically regulating the microenvironment to match tissue integration processes remains a challenge. Here, we construct a multilayer film on polyetheretherketone (PEEK) surface with different inner and outer layers of magnesium oxide (MgO) degradation rates. This film can sequentially regulate surface ions and immune microenvironment to achieve sequential antibacteria and bone integration. In the early stage of bone implantation, the outer layer of MgO can rapidly degrade to produce a strong alkaline microenvironment and a large amount of magnesium (Mg)

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12628059 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature