Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation.

ABSTRACT: The limited bone regeneration and suboptimal immune responses constitute the major challenges in repairing critical-sized bone defects. As an emerging therapeutic modality, mesenchymal stem cell-derived exosomes (MSC-Exos) exhibit promising application prospects in bone regeneration. In this study, the bone-functionalized MSC-Exos are loaded into GelMA hydrogel scaffolds modified with the bone immunomodulator Zeolitic Imidazolate Framework-8 (ZIF-8) for the repair of critical-sized bone defects. The prepared MSC-Exos/ZIF-8@GelMA composite hydrogel demonstrates excellent biocompatibility and favors the adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs). The sustained release of exosomes and zinc ions endows the composite hydrogel with synergistically enhanced bone rege

SUBMITTER: Si Y 

PROVIDER: S-EPMC12628064 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature