Biomimetic aligned bacterial cellulose dressing containing polydeoxyribonucleotide for promoting wound healing.

ABSTRACT: Chronic or non-healing wounds present a significant challenge in daily life, leading to increased interest in the design of wound dressings with enhanced healing capabilities. In this study, a bacterial cellulose (BC) membrane with an aligned structure was developed to guide cell migration and collagen orientation, serving as the primary component of the wound dressing. Polydeoxyribonucleotide (PDRN), a nucleic acid agent known for its excellent tissue-regenerative effect, were loaded into the aligned BC membrane. The obtained composite material (PDRN@BC aligned membrane) demonstrated aligned structure, high hydrophilicity, favorable air permeability, good mechanical properties, and sustained release of PDRN. The as-prepared membrane promoted cell spreading, proliferation and migration of

SUBMITTER: Zhu X 

PROVIDER: S-EPMC12628134 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature