3D printing of chitosan hydrogel reinforced with tubular nanoclay for hemostasis and infected wound healing.

ABSTRACT: Developing hydrogel dressings capable of rapid hemostasis and accommodating irregular wounds is crucial for infected wound healing. Customizable 3D-printed hydrogels, highly sought after for wound management, remain an ongoing challenge due to weak mechanical strength and low bioactivity. This work develops a nanoclay-enhanced, three-dimensional (3D) printed chitosan (CS) hydrogel for controlling bleeding and bacterial-infected wound healing. The hydrogen bonding and electrostatic attraction between halloysite clay nanotubes (HNTs) and CS endow the CS/HNTs ink with shear-thinning, excellent printability, high fidelity, and shape retention, allowing it to conform to irregular wound shapes. Incorporation of HNTs improved compressive/tensile strength and hemostatic performance of CS hydrogel.

SUBMITTER: Chen X 

PROVIDER: S-EPMC12628139 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature