Enhanced hematopoietic stem cell self-renewal and engraftment through human lung exosomal communication.

ABSTRACT: Hematopoietic stem cells (HSCs) are essential for sustaining the hematopoietic system throughout an individual's life. Within the HSC hierarchy, long-term HSCs are at the apex, maintaining the system by their unique capacity for self-renewal and differentiation into all blood cell lineages. Traditionally, it was believed that long-term HSC homeostasis is solely regulated within the bone marrow niche. However, our innovative single cell exosomal tracking analysis and in vivo transplantation studies revealed that lung cells play a significant role in this regulation through exosomal communication. Our in vivo primary and secondary engraftment studies demonstrate that exosomes derived from human primary small airway epithelial cells significantly enhance HSC engraftment. We developed a single

SUBMITTER: Benam SR 

PROVIDER: S-EPMC12628159 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature