Cerebrospinal fluid biomarkers for predicting immunotherapy response in autoimmune encephalitis.

ABSTRACT:

Objectives

This study aimed to investigate the predictive value of cerebrospinal fluid (CSF) biomarkers for immunotherapy response in patients with autoimmune encephalitis (AE).

Methods

We conducted a retrospective analysis of 80 patients with AE who were hospitalized at Zhongshan Hospital of Xiamen University between January 2014 and July 2024. Treatment response was evaluated using a combined assessment of the modified Rankin Scale (mRS) and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE) scores. Patients were classified into good response (n = 52, 65.0%) and poor response (n = 28, 35.0%) groups according to predefined criteria. Feature selection was performed using the Boruta algorithm and least absolute shrinkage and selection operator regression, followe

SUBMITTER: Gao W 

PROVIDER: S-EPMC12628214 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature