Targeting the FoxJ3/FoxO6 axis suppresses hepatocellular carcinoma growth by inducing cell cycle arrest and apoptosis.

ABSTRACT:

Objective

To explore the biological function of Forkhead box J3 (FoxJ3) in hepatocellular carcinoma (HCC).

Methods

FoxJ3 expression in HCC was analyzed using next-generation sequencing, and its association with overall survival and other Fox family proteins was evaluated. The biological roles of FoxJ3 and its relationship with Fox family members were investigated in vitro through MTT, cell cycle, and apoptosis assays. A xenograft model was established to assess the effects of FoxJ3 knockdown on tumor growth.

Results

FoxJ3 expression was significantly upregulated in HCC tissues, which was associated with poor prognosis and survival. Among Fox proteins family, forkhead box O6 (FoxO6) showed the strongest correlation with FoxJ3 expression. Furthermore, FoxJ3 knockdown su

SUBMITTER: Li W 

PROVIDER: S-EPMC12628247 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature